Which anthelmintic agent is commonly used to treat intestinal infections caused by roundworms?

Mebendazole is widely recognized as a first-line treatment for intestinal infections caused by roundworms, such as those from the Ascaris, Enterobius (pinworm), and Ancylostoma species. It functions by inhibiting the polymerization of tubulin, which disrupts microtubule formation in the parasitic worms. This mechanism prevents the worms from absorbing glucose, leading to their energy depletion and eventual death.

While albendazole could also be a potential choice because it is effective against a variety of helminths, including roundworms, mebendazole is traditionally preferred for specific roundworm infections due to its proven efficacy and safety profile in the intestinal context. Praziquantel is primarily used to treat infections caused by flukes and tapeworms, thus it is not suitable for roundworm infections. Ivermectin is commonly used for filarial infections and other ectoparasites, rather than intestinal roundworms.