Which agent is commonly used for the treatment of hookworm?

Mebendazole is widely recognized for its effectiveness against hookworm infections. It acts by inhibiting the polymerization of tubulin, which disrupts microtubule formation and impairs the parasite's ability to absorb glucose, leading to its energy depletion and eventual death. This mechanism is particularly effective against various helminths, including hookworms such as Ancylostoma duodenale and Necator americanus.

While other agents like albendazole and thiabendazole may also have activity against hookworms, mebendazole is often preferred due to its dosing regimen and safety profile. Pyrantel pamoate, although effective against some other intestinal helminths, is not as commonly used for hookworm treatment compared to mebendazole, making mebendazole the standard choice for this specific infection.