What is the primary function of mebendazole in treating helminthic infections?

Mebendazole primarily functions by inhibiting the reproductive capabilities of helminths. This mechanism is crucial as it prevents the worms from reproducing, effectively reducing their population within the host over time. By targeting the ability of the parasites to produce offspring, mebendazole helps to control and eventually eliminate the infection without necessarily killing the adult worms immediately.

Additionally, mebendazole acts by interfering with the worms' energy metabolism, which contributes to their eventual demise as the host's immune system clears the remaining worms. The inhibition of reproduction is particularly significant because it addresses the problem at its source, potentially leading to a more effective and sustained resolution of the infection. This differentiates it from strategies that might focus solely on reducing worm size or enhancing host immunity, which are not the primary functions of mebendazole.