What is the mechanism of action of Mebendazole?

Mebendazole operates primarily by inhibiting microtubule formation within the parasitic worms. This action interferes with the normal function of the cytoskeleton, which is crucial for many cellular processes in the parasite, including cell division, nutrient absorption, and overall structural integrity. By disrupting microtubule formation, Mebendazole effectively hinders the worm's ability to function and thrive, ultimately leading to its death. The significance of targeting microtubules lies in their role in cellular transport and division processes, which are essential for the growth and reproduction of the parasites, making this mechanism particularly effective for treating infections caused by various helminths.

In contrast, while some other agents may affect DNA synthesis, glucose absorption, or cellular membranes, these do not apply to Mebendazole's action, which is specific to microtubule inhibition. This specificity allows Mebendazole to be effective against a range of intestinal worms, providing a focused therapeutic approach in anthelmintic therapy.