Is mebendazole rapidly metabolized by the liver?

Mebendazole is not rapidly metabolized by the liver; rather, it is primarily excreted unchanged in the feces. Its metabolism is minimal, which means that a significant portion of the drug remains intact as it is passed through the digestive system. This characteristic is beneficial for its action against intestinal parasites, as it allows for effective drug concentrations to be maintained in the gastrointestinal tract, where the parasites reside.

While there may be some metabolic processes occurring, they are not extensive enough to classify mebendazole as rapidly metabolized. Understanding the pharmacokinetics of mebendazole is crucial, as it helps in recognizing how the drug functions and why it is effective in treating infections caused by helminths.