In which of the following is Ivermectin primarily indicated?

Ivermectin is primarily indicated for the treatment of onchocerciasis, also known as river blindness. This parasitic infection is caused by the filarial worm Onchocerca volvulus, which is transmitted to humans through the bite of infected blackflies. Ivermectin works effectively by targeting the microfilariae (larval forms) of the parasite, paralyzing and killing them, which reduces the symptoms and potential complications associated with the disease.

The selection of Ivermectin for onchocerciasis is based on its efficacy and safety profile. It has been shown to significantly reduce the number of microfilariae in patients, leading to improvement in ocular health and a decrease in the transmission of the disease in endemic areas. The World Health Organization has endorsed Ivermectin as a key element in the strategy to control and eliminate onchocerciasis in affected regions.

While Ivermectin is also used to treat other conditions, such as scabies and certain types of worm infections, its primary and most established use remains in the treatment of onchocerciasis.